The cornerstone of neuromonitoring in this setting remains neurological examination, which is often simplified using clinical scales, together with the initial assessment of brain injuries. As such, specific non-invasive and invasive neuro-monitoring systems have been implemented in clinical practice for TBI patients. In the absence of early detection and prompt therapeutic response, these secondary injuries can lead to death or severe disability. The initial injury is often associated with the occurrence of secondary injuries, such as tissue hypoxia, seizures, or cerebral edema, which light further complicate with the development of intracranial hypertension and cerebral herniation. Traumatic brain injury (TBI), with its variety in cerebral consequences (i.e., mild, moderate or severe), is one of leading causes of global morbidity and death, primarily in European countries. Conclusions: Low NPi on admission has limited prognostic value in TBI. However, in a generalized linear model, the prognostic role of NPi on admission was limited. Median worst and mean NPi on admission were significantly lower in the UO group than others (3.9 (1.7–4.4) vs. ![]() On admission, 20 (20%) patients had an abnormal NPi (NPi < 3) median worst (i.e., from both eyes) NPi was 4.2 (3.2–4.5). Results: 100 patients were included over the study period (median age 48 (34–69) years and median GCS on admission 11 (6–15)) 49 (49%) patients had UO. ![]() Unfavorable neurological outcome (UO) at hospital discharge was considered for a Glasgow Outcome Scale of 1–3. Methods: Retrospective observational study including adult (>18 years) TBI patients admitted from January 2018 to December 2020, with available NPi on admission. Background: The aim of this study was to evaluate whether the early assessment of neurological pupil index (NPi) values derived from automated pupillometry could predict neurological outcome after traumatic brain injury (TBI).
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